Dronedarone (By mouth)
Treats serious heart rhythm problems in patients with a history of atrial fibrillation or atrial flutter.
MultaqThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:You should not use this medicine if you have had an allergic reaction to dronedarone, or if you are pregnant, planning to become pregnant, or breastfeeding. You should not use this medicine if you have heart failure, heart block, a prolonged QT or PR heart interval, sick sinus syndrome (an abnormal heart rhythm), a slow heartbeat, or severe liver disease. Do not use this medicine if you are also using any of these medications: cyclosporine (Gengraf®, Neoral®, Sandimmune®), ritonavir (Norvir®), medicine for depression (such as amitriptyline, nefazodone, nortriptyline, Elavil®, Pamelor®, Serzone®, or Vivactil®), medicine for heart rhythm problems (such as amiodarone, disopyramide, dofetilide, flecainide, propafenone, quinidine, sotalol, Cardioquin®, Cordarone®, Norpace®, Rhythmol®, or Tikosyn®), medicine for infections (such as clarithromycin, erythromycin, ketoconazole, itraconazole, telithromycin, voriconazole, Biaxin®, Ery-tab®, Ketek®, Nizoral®, Sporanox®, or Vfend®), or a phenothiazine medicine (such as chlorpromazine, prochlorperazine, promethazine, thioridazine, Compazine®, Mellaril®, Phenergan®, Thorazine®, or Trilafon®).
How to Use This Medicine:
- Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
- It is best to take this medicine with food or milk.
- This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one. Your doctor might ask you to sign some forms to show that you understand this information.
If a dose is missed:
- If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine:
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are also using carbamazepine (Tegretol®), digoxin (Lanoxin®), phenobarbital (Luminal®), phenytoin (Dilantin®), rifampin (Rifadin®, Rimactane®), simvastatin (Zocor®), sirolimus (Rapamune®), tacrolimus (Prograf®), or St. John's wort. Tell your doctor if you are also using a diuretic or water pill (such as spironolactone, triamterene, or Aldactone®) or blood pressure medicine (such as atenolol, diltiazem, labetalol, metoprolol, nifedipine, propranolol, timolol, verapamil, Cardizem®, Inderal®, Lotrel®, Norvasc®, Plendil®, or Toprol®).
- Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
Warnings While Using This Medicine:
- Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
- Make sure your doctor knows if you have liver disease, a history of heart failure, or low potassium or magnesium in the blood.
- Tell your doctor right away if you develop any of the following: chest pain; shortness of breath; swelling of your hands, ankles, or feet; or weight gain. These may be symptoms of heart failure.
- This medicine can cause changes in your heart rhythm, such as a condition called QT prolongation. It may cause fainting or serious side effects in some patients. Contact your doctor right away if you have any symptoms of heart rhythm problems, such as fast, pounding or uneven heartbeats.
- Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments. Blood tests may be needed to check for unwanted effects.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
- Change in how much or how often you urinate.
- Chest pain.
- Coughing up a frothy sputum.
- Dry mouth, increased thirst, muscle cramps, nausea, or vomiting.
- Fast, slow, pounding or uneven heartbeat.
- Rapid weight gain.
- Shortness of breath or trouble breathing.
- Swelling in your hands, ankles, or feet.
- Trouble with sleeping.
If you notice these less serious side effects, talk with your doctor:
- Mild nausea, vomiting, diarrhea, stomach pain, or upset stomach.
- Lack or loss of strength.
- Rash or itching skin.
- Unpleasant taste in your mouth.
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088Last Updated:
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